RS 49676
RS 49676 is an N-substituted imidazole compound that exhibits strong in vitro activity against endogenous amoebae (ED50 < 0.1 ng/mL), but is ineffective against exogenous amoebae (epimastigotes) . In vivo, RS 49676 (100 mg/kg/d, sc, 2 times) can prolong the average survival time of mice infected with Trypanosoma cruzi to more than 11 weeks.
Product Specifications
CAS Number
111962-89-1
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rs-49676.html
Smiles
ClC(C=C1)=CC=C1CC[C@@]2(O[C@H](CO2)COC3=CC=C(C=C3)NC(OCC)=O)CN4C=CN=C4
Molecular Formula
C25H28ClN3O5
Molecular Weight
485.96
References & Citations
[1]The efficacy of an N-substituted imidazole, RS-49676, against a Trypanosoma cruzi infection in mice.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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