AF-353 (hydrochloride)
AF-353 hydrochloride is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].
Product Specifications
CAS Number
927887-18-1
Product Name Alternative
Ro-4 (hydrochloride)
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/af-353-hydrochloride.html
Smiles
IC1=C(OC)C=C(C(C)C)C(OC2=CN=C(N)N=C2N)=C1.Cl
Molecular Formula
C14H18ClIN4O2
Molecular Weight
436.68
References & Citations
[1]Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160 (6) :1387-1398.|[2]Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110 (8 Pt B) :E409-414.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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