Salinomycin (sodium salt) (Standard)

Salinomycin (sodium salt) (Standard) is the analytical standard of Salinomycin (sodium salt) . This product is intended for research and analytical applications. Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem cells[1][2][3].

Product Specifications

CAS Number

[55721-31-8]

Product Name Alternative

Salinomycin sodium (Standard) ; Sodium salinomycin (Standard)

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Autophagy; Bacterial; Parasite; Reference Standards; Wnt; β-catenin

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Autophagy; Others; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/salinomycin-sodium-salt-standard.html

Purity

99.69

Smiles

[H][C@]1([C@](C)(CC2)O[C@]32[C@H](O)C=C[C@]4(O[C@]([H])([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@]5([H])O[C@]([C@@H](CC)C(O[Na])=O)([H])CC[C@@H]5C)=O)[C@@H](C)C[C@H]4C)O3)CC[C@@](CC)(O)[C@H](C)O1

Molecular Formula

C42H69NaO11

Molecular Weight

772.98

References & Citations

[1]Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108 (32) :13253-7.|[2]Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222 (2) :139-45.|[3]Klose J, et al. Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. PLoS One. 2019 Feb 14;14 (2) :e0211916.|[4]Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012; 7 (12) : e50638.|[5]Qu H, et al. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med. 2015 Jul;8 (7) :578-82.