7-Hydroxyflavone

7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC) -associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active[1][2][4].

Product Specifications

CAS Number

[6665-86-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; COX; Enterovirus; ERK; Keap1-Nrf2; Lipoxygenase; Pyruvate Kinase; Virus Protease

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/7-hydroxyflavone.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=CC=C13

Molecular Formula

C15H10O3

Molecular Weight

238.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Vinutha K, et al. Aqueous extract from Madhuca indica bark protects cells from oxidative stress caused by electron beam radiation: in vitro, in vivo and in silico approach. Heliyon. 2019 May 30;5 (5) :e01749.|[2]Sengupta B, et al. Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells. PLoS One. 2017 Jun 22;12 (6) :e0179777.