PROTAC HIF-1α degrader-1

PROTAC HIF-1α degrader-1 (compound V2) is a potent hypoxia-inducible factor-1α (HIF-1α) PROTAC degrader with an IC50 value of 7.54 µM. PROTAC HIF-1α degrader-1 shows anti-proliferative activity. PROTAC HIF-1α degrader-1 decreases the HIF-1α protein expression. PROTAC HIF-1α degrader-1 induces apoptosis. (Pink: ligand for target protein (HY-111387) ; black: linker (HY-W013731) ; Blue: E3 ligase ligand (HY-112078) ) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; HIF/HIF Prolyl-Hydroxylase; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-hif-1α-degrader-1.html

Purity

98.02

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(CCOCCOCCN[C@@H](C(C)(C)C)C(N2[C@H](C(N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)=O)C[C@@H](O)C2)=O)CC1)COC5=CC=C(C67C[C@H](C[C@H](C7)C8)C[C@H]8C6)C=C5

Molecular Formula

C51H72N6O7S

Molecular Weight

913.22

References & Citations

[1]Li Y, et al. Discovery of potent hypoxia-inducible factor-1α (HIF-1α) degraders by proteolysis targeting chimera (PROTAC) . Bioorg Chem. 2024 Nov 4;153:107943.