Elcubragistat
Elcubragistat (ABX-1431) is a highly potent, selective, and orally available, CNS-penetrant monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 14 nM.
Product Specifications
CAS Number
[1446817-84-0]
Product Name Alternative
ABX-1431
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/elcubragistat.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2N3CCCC3)CC1)OC(C(F)(F)F)C(F)(F)F
Molecular Formula
C20H22F9N3O2
Molecular Weight
507.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Cisar JS, et al. Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders. J Med Chem. 2018 Oct 25;61 (20) :9062-9084.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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