β-Benzamide adenine dinucleotide
β-Benzamide adenine dinucleotide is a bioactive metabolite of benzamide nucleoside and a potent inhibitor of inosine 5 '-monophosphate dehydrogenase (IMPDH) . β-Benzamide adenine dinucleotide is a potent, competitive inhibitor of human NAD kinase (Ki = 90 µM) [1][2].
Product Specifications
CAS Number
156724-91-3
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/β-benzamide-adenine-dinucleotide.html
Smiles
O[C@@H]1[C@H](O)[C@@H](COP(OP(OC[C@@H]2[C@@H](O)[C@@H](O)[C@H](C3=CC=CC(C(N)=O)=C3)O2)(O)=O)(O)=O)O[C@H]1N(C=N4)C5=C4C(N)=NC=N5
Molecular Formula
C22H28N6O14P2
Molecular Weight
662.44
References & Citations
[1]Lesiak K, et al. Synthesis of nonhydrolyzable analogues of thiazole-4-carboxamide and benzamide adenine dinucleotide containing fluorine atom at the C2' of adenine nucleoside: induction of K562 differentiation and inosine monophosphate dehydrogenase inhibitory activity. J Med Chem. 1997 Aug 1;40 (16) :2533-8.|[2]Bonnac L, et al. Probing binding requirements of NAD kinase with modified substrate (NAD) analogues. Bioorg Med Chem Lett. 2007 Mar 15;17 (6) :1512-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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