PLTX-II

PLTX-II is a calcium channel blocker. PLTX-II has a 44-residue peptide containing ten Cys residues and an O-palmitoylated threonine amide at the carboxy-terminus[1].

Product Specifications

UNSPSC

12352209

Target

Calcium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pltx-ii.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](OC(CCCCCCCCCCCCCCC)=O)C)C(N)=O)=O)=O)NC1=O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@H]3[C@H](O)C)=O)=O)=O)=O)=O)NC4=O)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@H](C(N[C@H]5CCCNC(N)=N)=O)NC6=O)C(NCC(N[C@@H]([C@H](O)C)C(N7[C@@H](CCC7)C(N[C@@H](CC8=CNC9=CC=CC=C89)C(NCC(N[C@@H](C)C(N[C@H]6CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC%10=CNC=N%10)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC%11=CC=C(C=C%11)O)C(N[C@@H](CC%12=CC=C(C=C%12)O)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@H]1CCCNC(N)=N)=O)=O)=O)=O)=O)=O)NC5=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Molecular Formula

C208H313N61O70S10

Molecular Weight

5108.73

References & Citations

[1]J Bódi, et al. Synthesis of an O-palmitoylated 44-residue peptide amide (PLTX II) blocking presynaptic calcium channels in Drosophila. Pept Res. 1995, 84, 4.