2- (Methylamino) -1H-purin-6 (7H) -one

2- (Methylamino) -1H-purin-6 (7H) -one (N2-Methylguanine) is a modified nucleoside. 2- (Methylamino) -1H-purin-6 (7H) -one is an endogenous methylated nucleoside found in human fluids.

Product Specifications

CAS Number

[10030-78-1]

Product Name Alternative

N2-methylguanine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; DNA/RNA Synthesis; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/N2-Methylguanine.html

Purity

98.0

Solubility

DMSO : < 1 mg/mL|Ethanol : < 1 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C1N=C(NC)NC2=C1NC=N2

Molecular Formula

C6H7N5O

Molecular Weight

165.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Rife JP, et al. N 2-methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops. Nucleic Acids Res. 1998 Aug 15;26 (16) :3640-4.|[2]Youvan DC, et al. Reverse transcriptase pauses at N2-methylguanine during in vitro transcription of Escherichia coli 16S ribosomal RNA. Proc Natl Acad Sci U S A. 1979 Aug;76 (8) :3751-4.