Moracin M

Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[56317-21-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Autophagy; Endogenous Metabolite; NF-κB; Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

Autophagy; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/moracin-m.html

Concentration

10mM

Purity

98.99

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

OC1=CC(C2=CC3=CC=C(O)C=C3O2)=CC(O)=C1

Molecular Formula

C14H10O4

Molecular Weight

242.23

Precautions

H315, H319, H335

References & Citations

[1]Chen SK, et al. Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2012 May 1;22 (9) :3261-4.|[2]Lee JH, et al. Moracin M inhibits airway inflammation by interrupting the JNK/c-Jun and NF-κB pathways in vitro and in vivo. Eur J Pharmacol. 2016;783:64-72.|[3]Guo F, et al. Moracin M inhibits lipopolysaccharide-induced inflammatory responses in nucleus pulposus cells via regulating PI3K/Akt/mTOR phosphorylation. Int Immunopharmacol. 2018 May;58:80-86.