AAA
AAA is a potent blocker of 20-Hydroxyeicosatetraenoic acid (20-HETE) receptor that binds directly to GPR75 and prevents the increases in intracellular Ca2+, IP-1 and β-arrestin[1].
Product Specifications
UNSPSC
12352211
Target
Orphan GPCR; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aaa.html
Purity
99
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC(CCCC/C=C\CCCCCCC/C=C\CCCCO)=O)CC(O[Na])=O)O[Na]
Molecular Formula
C24H39NNa2O6
Molecular Weight
483.55
References & Citations
[1]Jonathan V. Pascale, et al. 20-Hydroxyeicosatetraenoic acid (20-HETE) : Bioactions, receptors, vascular function, cardiometabolic disease and beyond. Adv Pharmacol. 2023; 97: 229–255.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Available Sizes
Curated Selection
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