LolCDE-IN-4
LolCDE-IN-4 (Compound 1) is exhibits antibacterial efficacy against gram negative bacteria Escherichia coli (MIC of 0.25-32 µg/ml) and Haemophilus influenzae, through inhibition LolCDE complex and disruption of lipoproteins release from the inner membrane[1].
Product Specifications
CAS Number
1859918-13-0
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lolcde-in-4.html
Purity
99.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=NC(C2=CC=NC=C2)=C(C3=CC=C(OCCO4)C4=C3)N1)(C)C
Molecular Formula
C20H21N3O2
Molecular Weight
335.40
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
References & Citations
[1]McLeod SM, et al., Small-molecule inhibitors of gram-negative lipoprotein trafficking discovered by phenotypic screening. J Bacteriol. 2015 Mar;197 (6) :1075-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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