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LolCDE-IN-4

LolCDE-IN-4 (Compound 1) is exhibits antibacterial efficacy against gram negative bacteria Escherichia coli (MIC of 0.25-32 µg/ml) and Haemophilus influenzae, through inhibition LolCDE complex and disruption of lipoproteins release from the inner membrane[1].

Product Specifications

CAS Number

[1859918-13-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/lolcde-in-4.html

Purity

99.39

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1=NC(C2=CC=NC=C2)=C(C3=CC=C(OCCO4)C4=C3)N1)(C)C

Molecular Formula

C20H21N3O2

Molecular Weight

335.40

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

References & Citations

[1]McLeod SM, et al., Small-molecule inhibitors of gram-negative lipoprotein trafficking discovered by phenotypic screening. J Bacteriol. 2015 Mar;197 (6) :1075-82.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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