SGLT2-IN-1

SGLT2-IN-1 (Compound 5) is an inhibitor for sodium-dependent glucose cotransporter (SGLT2), with IC50 of 33 nM in CHO cells transfected with human SGLT2. SGLT2-IN-1 is selective for SGLT2 over SGLT1. SGLT2-IN-1 is an active metabolite of dapagliflozinactive metabolite of dapagliflozin[1][2].

Product Specifications

CAS Number

[864070-37-1]

UNSPSC

12352005

Hazard Statement

H302, H319, H372, H411

Target

SGLT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sglt2-in-1.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@H](C2=CC(CC3=CC=C(C=C3)O)=C(C=C2)Cl)O[C@@H]([C@H]([C@@H]1O)O)CO

Molecular Formula

C19H21ClO6

Molecular Weight

380.82

Precautions

H302, H319, H372, H411

References & Citations

[1]Lansdell MI, et al., Design and synthesis of fluorescent SGLT2 inhibitors. Bioorg Med Chem Lett. 2008 Sep 15;18 (18) :4944-7. |[2]Xu B, Feng Y, et al. C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2011 Aug 1;21 (15) :4465-70.