Malachite green (hemioxalate)

Malachite green hemioxalate (MCCK1) is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate has antibacterial activity, which is attributed to inhibition of intracellular enzymes, insertion into DNA and/or interaction with cell membranes. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo[1][2][3].

Product Specifications

CAS Number

[2437-29-8]

Product Name Alternative

MCCK1

UNSPSC

12171500

Hazard Statement

H301, H318, H361, H410

Target

Apoptosis; Fungal; IKK; NF-κB

Type

Dye Reagents

Related Pathways

Anti-infection; Apoptosis; NF-κB

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/malachite-green-hemioxalate.html

Purity

98.0

Solubility

DMSO : ≥ 10 mg/mL

Smiles

C/[N+](C)=C1C=C/C(C=C/1)=C(C2=CC=C(N(C)C)C=C2)\C3=CC=CC=C3.O=C(O)C([O-])=O.O=C(O)C(O)=O.[1/2]

Molecular Formula

C23H25N2.1/2C2H2O4.C2HO4

Molecular Weight

463.50

Precautions

H301, H318, H361, H410

References & Citations

[1]Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87.|[2]Lawton, J. R. The use of malachite green during fixation of plant tissues for the preservation of lipids. Journal of Microscopy, 1986, 144 (2), 201-209. |[3]Culp SJ, et al. Toxicity and metabolism of malachite green and leucomalachite green during short-term feeding to Fischer 344 rats and B6C3F1 mice. Chem Biol Interact. 1999 Nov 1;122 (3) :153-70.