L-Palmitoylcarnitine-d3 (hydrochloride)

L-Palmitoylcarnitine-d3 hydrochloride is the deuterium labeled L-Palmitoylcarnitine hydrochloride. L-Palmitoylcarnitine hydrochloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine hydrochloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].

Product Specifications

CAS Number

[1334532-26-1]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; Potassium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Cardiovascular Disease

Purity

99.94

Solubility

DMF : ≥ 20mg/mL|DMSO : ≥ 10mg/mL|Ethanol : ≥ 20mg/mL|H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCCCCCCCCCCCCC(O[C@H](CC(O)=O)C[N+](C)(C)C([2H])([2H])[2H])=O.[Cl-]

Molecular Formula

C23H43D3ClNO4

Molecular Weight

439.09

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K (ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441 (2-3) :200-207.