Boc-bipiperidine-ethynylbenzoic acid
Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61[1]. Boc-bipiperidine-ethynylbenzoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
2308497-81-4
UNSPSC
12352005
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/boc-bipiperidine-ethynylbenzoic-acid.html
Purity
99.19
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)C#CC2CCN(C3CCN(CC3)C(OC(C)(C)C)=O)CC2)O
Molecular Formula
C24H32N2O4
Molecular Weight
412.52
References & Citations
[1]Lijie Zhao, et al. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22 (10) :522-532.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers
Available Sizes
Frequently Asked Questions
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