Boc-bipiperidine-ethynylbenzoic acid

Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61[1]. Boc-bipiperidine-ethynylbenzoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2308497-81-4]

UNSPSC

12352005

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/boc-bipiperidine-ethynylbenzoic-acid.html

Purity

99.19

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C=C1)C#CC2CCN(C3CCN(CC3)C(OC(C)(C)C)=O)CC2)O

Molecular Formula

C24H32N2O4

Molecular Weight

412.52

References & Citations

[1]Lijie Zhao, et al. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22 (10) :522-532.