BET-IN-19
BET-IN-19 (Compound 146) is a BET inhibitor. BET-IN-19 inhibits hlL-6 mRNA transcription (IC50 ≤0.3 uM), and c-myc activity in human AML MV4-11 cell (IC50 ≤0.3 uM) 。BET-IN-19 inhibits tetra-acetylated histone H4 binding to BRD4 bromodomain 1 (IC50 ≤0.3 uM) [1].
Product Specifications
CAS Number
1643947-30-1
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bet-in-19.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CNC1=NC(N=CC(C2=C(C)ON=C2C)=C3)=C3N1CC4=CC=CC=C4
Molecular Formula
C19H19N5O
Molecular Weight
333.39
References & Citations
[1]Bryan Cordell DUFFY, et al. Novel bicyclic bromodomain inhibitors. Patent. WO2015002754 A2.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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