N4Py
N4Py is a pentadentate ligand, that forms a stable complex with metal ions, such as iron, platinum, and copper. N4py mimics the metal binding domains of iron-dependent antibiotics like Bleomycin , forms the DNA-cleaving FeII-N4Py complexes, generates reactive oxygen species (ROS), and causes oxidative damage in cells. N4py can be used in cancer research[1].
Product Specifications
CAS Number
167695-87-6
UNSPSC
12352005
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n4py.html
Smiles
C1(C(C2=CC=CC=N2)N(CC3=CC=CC=N3)CC4=NC=CC=C4)=NC=CC=C1
Molecular Formula
C23H21N5
Molecular Weight
367.45
References & Citations
[1]Geersing A, et al., Importance of Metal-Ion Exchange for the Biological Activity of Coordination Complexes of the Biomimetic Ligand N4Py. Inorg Chem. 2018 Jul 2;57 (13) :7748-7756.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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