Smurf1-IN-A01
Product Specifications
UNSPSC Description
Smurf1-IN-A01 is a Smurf1 inhibitor. Smurf1-IN-A01 has anticancer activity and can be used for the research of osteoporosis and age-related macular degeneration[1][2][3][4].
Target Antigen
Estrogen Receptor/ERR; HSP; Interleukin Related; MyD88; NF-κB
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Vitamin D Related/Nuclear Receptor
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/smurf1-in-a01.html
Purity
99.81
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(C(F)(F)F)=C(Cl)C=C1)(N2CCN(C(C3=CC=C(N4C(C)=CC=N4)C=C3)=O)CC2)=O
Molecular Weight
512.93
References & Citations
[1]Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965.|[2]Li F, et al. C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity [J]. Nature Communications, 2023, 14(1): 6718.|[3]Qu M, et al. HSP90β chaperoning SMURF1-mediated LATS proteasomal degradation in the regulation of bone formation [J]. Cellular Signalling, 2023, 102: 110523.|[4]Yang H, et al. SMURF1 facilitates estrogen receptor ɑ signaling in breast cancer cells [J]. Journal of experimental & clinical cancer research, 2018, 37(1): 1-12.|[5]Li D, et al. Smurf1: A possible therapeutic target in dry age-related macular degeneration [J]. Experimental Eye Research, 2023, 233: 109549.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-110195/Smurf1-IN-A01-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-110195/Smurf1-IN-A01-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1007647-73-5
Available Sizes
Curated Selection
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