1- (β-D-Ribofuranosyl) -5-nitropyrine-2 (1H) -one
1- (β-D-Ribofuranosyl) -5-nitropyrine-2 (1H) -one is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[59892-36-3]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-β-d-ribofuranosyl-5-nitropyrine-2-1h-one.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(C=CC([N+]([O-])=O)=C2)=O)O1
Molecular Formula
C10H12N2O7
Molecular Weight
272.21
Precautions
P264-P270-P280-P302+P352-P330-P362+P364-P501
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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