CFM-5

CFM-5 inhibits CARP-1/CCAR1-APC-2 interaction with an IC50 value of 0.75 μM. CFM-5 inhibits medulloblastoma (MB) cell proliferation and induces apoptosis[1][2].

Product Specifications

CAS Number

[639507-03-2]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cfm-5.html

Concentration

10mM

Purity

99.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C2=C(C13SC(C4=CC=CC=C4)=NN3)C=C(C=C2)Br)CCC5=CC=CC=C5

Molecular Formula

C23H18BrN3OS

Molecular Weight

464.38

References & Citations

[1]Abdelkader E Ashour, et al. CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS One. 2013 Jun 24;8 (6) :e66733.|[2]Magesh Muthu, et al. CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis. Oncotarget. 2015 Mar 30;6 (9) :6499-510.