CFM-5
CFM-5 inhibits CARP-1/CCAR1-APC-2 interaction with an IC50 value of 0.75 μM. CFM-5 inhibits medulloblastoma (MB) cell proliferation and induces apoptosis[1][2].
Product Specifications
CAS Number
[639507-03-2]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cfm-5.html
Concentration
10mM
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2=C(C13SC(C4=CC=CC=C4)=NN3)C=C(C=C2)Br)CCC5=CC=CC=C5
Molecular Formula
C23H18BrN3OS
Molecular Weight
464.38
References & Citations
[1]Abdelkader E Ashour, et al. CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS One. 2013 Jun 24;8 (6) :e66733.|[2]Magesh Muthu, et al. CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis. Oncotarget. 2015 Mar 30;6 (9) :6499-510.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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