1,2-Cyclohexanedione

1,2-Cyclohexanedione is an arginine modification reagent. 1,2-Cyclohexanedione interferes with the degradation of low-density lipoprotein by modifying the arginine group in apolipoprotein. 1,2-Cyclohexanedione can be used in the research of familial hypercholesterolemia[1][2][3].

Product Specifications

CAS Number

[765-87-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents; LDLR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/1-2-cyclohexanedione.html

Purity

99.24

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(CCCC1)=O

Molecular Formula

C6H8O2

Molecular Weight

112.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Baker GF, et al. Glucose transport inhibitors protect against 1,2-cyclohexanedione-produced potassium loss from human red blood cells. Exp Physiol. 1998 Mar;83 (2) :239-42.|[2]Knight BL, et al. Degradation by cultured fibroblasts and macrophages of unmodified and 1,2-cyclohexanedione-modified low-density lipoprotein from normal and homozygous familial hypercholesterolaemic subjects. Biochem J. 1982 Jan 15;202 (1) :145-52. |[3]Lanza L, et al. Identification and Characterization of Thiamine Diphosphate-Dependent Lyases with an Unusual CDG Motif. Angew Chem Int Ed Engl. 2024 Aug 19;63 (34) :e202404045.