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Yaddle1

Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC50) of 0.40 μM. Yaddle1 can significantly trigger Ca2+ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants[1].

Product Specifications

CAS Number

[3041134-13-5]

UNSPSC

12352005

Target

Piezo Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/yaddle1.html

Purity

99.14

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

ClC1=C(CSC2=NN=C(C3=NC=CN=C3)O2)C(C(F)(F)F)=CC=C1

Molecular Formula

C14H8ClF3N4OS

Molecular Weight

372.75

References & Citations

[1]Goon S, et al. Exploring the Structural Attributes of Yoda1 for the Development of New-Generation Piezo1 Agonist Yaddle1 as a Vaccine Adjuvant Targeting Optimal T Cell Activation. J Med Chem. 2024;67 (10) :8225-8246.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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