Yaddle1
Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC50) of 0.40 μM. Yaddle1 can significantly trigger Ca2+ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants[1].
Product Specifications
CAS Number
[3041134-13-5]
UNSPSC
12352005
Target
Piezo Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/yaddle1.html
Purity
99.14
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC1=C(CSC2=NN=C(C3=NC=CN=C3)O2)C(C(F)(F)F)=CC=C1
Molecular Formula
C14H8ClF3N4OS
Molecular Weight
372.75
References & Citations
[1]Goon S, et al. Exploring the Structural Attributes of Yoda1 for the Development of New-Generation Piezo1 Agonist Yaddle1 as a Vaccine Adjuvant Targeting Optimal T Cell Activation. J Med Chem. 2024;67 (10) :8225-8246.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2576310-01 24 Tests (Limit 1)
High Sensitivity Human IL-1 beta (Interleukin 1 Beta) ELISA Kit
Ask
View Details 
MBS2576310-02 48 Tests
High Sensitivity Human IL-1 beta (Interleukin 1 Beta) ELISA Kit
Ask
View Details MBS2576310-03 96 Tests
High Sensitivity Human IL-1 beta (Interleukin 1 Beta) ELISA Kit
Ask
View Details 
MBS2576310-04 5x 96 Tests
High Sensitivity Human IL-1 beta (Interleukin 1 Beta) ELISA Kit
Ask
View Details MBS2576310-05 10x 96 Tests
High Sensitivity Human IL-1 beta (Interleukin 1 Beta) ELISA Kit
Ask
View Details