FR260330
FR260330 is a selective, orally active inhibitor for inducible nitric oxide synthase (iNOS) through suppression of iNOS dimerization. FR260330 inhibits the NO accumulation in rat splenocytes and human DLD-110 cells, with IC50 of 27 and 10 nM. FR260330 ameliorates the Lipopolysaccharides (HY-D1056) -induced inflammatory diseases in rats model[1].
Product Specifications
CAS Number
[442198-67-6]
UNSPSC
12352005
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fr260330.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(OC2=NC=NC(C(F)(F)F)=C2)CC1)CNC([C@@H](NC(/C=C/C3=CC=C(Cl)C=C3)=O)CC4=CC=CC=N4)=O
Molecular Formula
C29H28ClF3N6O4
Molecular Weight
617.02
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
INOS
Available Sizes
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