AMG580

AMG580 is a selective PDE10A antagonist with subnanomolar affinity for rat, primate, and human PDE10A. AMG580 can be used for the research of noninvasive radiotracer[1].

Product Specifications

CAS Number

[1227067-71-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amg580.html

Smiles

O=C(C1=NC2=C(N1)C=CC=C2)C3=CC=C(C=C3)OC4=NC=CN=C4C5CCN(CC5)C(C(C)F)=O

Molecular Formula

C26H24FN5O3

Molecular Weight

473.50

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Chen H, et al. AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer. J Pharmacol Exp Ther. 2015 Feb;352 (2) :327-37.