Spastazoline
Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research[1].
Product Specifications
CAS Number
2351882-11-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Spastazoline.html
Purity
98.50
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C)C1=CC(NC2=NC(N3CCN[C@H](C(C)C)C3)=NC4=C2C=CN4)=NN1
Molecular Formula
C20H30N8
Molecular Weight
382.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb 18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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