Delequamine

Delequamine (RS-15385-197) is an orally active and selective α2-adrenergic receptor antagonist with a pKi of 9.5 for α2-adrenoceptors in rat cortex. Delequamine shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine can be used for the study of erectile dysfunction[1].

Product Specifications

CAS Number

[119905-05-4]

Product Name Alternative

RS-15385-197

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/delequamine.html

Solubility

10 mM in DMSO

Smiles

CS(=O)(N1[C@@]2([H])C[C@@]3([H])C4=CC=C(OC)C=C4CCN3C[C@@]2([H])CCC1)=O

Molecular Formula

C18H26N2O3S

Molecular Weight

350.48

References & Citations

[1]Tallentire D, et al. Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197) . Br J Pharmacol. 1996;118 (1) :63-72.