SB-236057
Product Specifications
UNSPSC Description
SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis[1].
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sb-236057.html
Smiles
O=C(N1C2=CC3=C(C=C2CC1)OCC34CCN(CC4)CC)C5=CC=C(C6=C(C)C=C(C7=NN=C(C)O7)C=C6)C=C5
Molecular Weight
534.65
References & Citations
[1]Augustine‐Rauch K A, et al. Evidence for a molecular mechanism of teratogenicity of SB‐236057, a 5‐HT1B receptor inverse agonist that alters axial formation[J]. Birth Defects Research Part A: Clinical and Molecular Teratology, 2004, 70(10): 789-807.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116603/SB-236057-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116603/
Clinical Information
No Development Reported
CAS Number
180083-49-2
Curated Selection
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