Fluticasone (propionate)

Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

Product Specifications

CAS Number

[80474-14-2]

UNSPSC

12352100

Hazard Statement

H315, H319, H320

Target

ADC Payload; Endogenous Metabolite; Enterovirus; Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Infection; Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Fluticasone-propionate.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(CC)O[C@@]([C@]([C@@]1([H])C2)(C[C@H](O)[C@](F)([C@]3(C=C4)C)[C@@]1([H])C[C@H](F)C3=CC4=O)C)([C@@H]2C)C(SCF)=O

Molecular Formula

C25H31F3O5S

Molecular Weight

500.57

Precautions

H315, H319, H320

References & Citations

[1]Singanayagam A, et al. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26;385 Suppl 1:S88.|[2]Bryson HM, et al. Intranasal fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in allergic rhinitis. Drugs. 1992;43 (5) :760-775.|[3]Johnson M. The anti-inflammatory profile of fluticasone propionate. Allergy. 1995;50 (23 Suppl) :11-14.