Human Activated Protein C DEGR (active site blocked)

<strong>Human Activated Protein C DEGR (active site blocked)</strong>_x000D_ <strong>Catalog number:</strong> B2016618_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 µg _x000D_ <strong>Molecular Weight or Concentration:</strong> 56200_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −20°C_x000D_ <strong>Keywords:</strong> Human Activated Protein C - DEGR (active site blocked)_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong> _x000D_ 1: Yegneswaran S, Deguchi H, Griffin JH. Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles J Biol Chem. 2003 Apr 25;278(17):14614-21. _x000D_ 2: Mizutani A, Okajima K, Uchiba M, Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation Blood. 2000 Jun 15;95(12):3781-7._x000D_ 3: Yamaguchi Y, Hisama N, Okajima K, Uchiba M, Murakami K, Takahashi Y, Yamada S, Mori K, Ogawa M. Pretreatment with activated protein C or active human urinary thrombomodulin attenuates the production of cytokine-induced neutrophil chemoattractant following ischemia/reperfusion in rat liver Hepatology. 1997 May;25(5):1136-40. _x000D_ 4: Takeyama M, Wakabayashi H, Fay PJ. Contribution of factor VIII light-chain residues 2007-2016 to an activated protein C-interactive site Thromb Haemost. 2013 Feb;109(2):187-98. _x000D_ 5: Yegneswaran S, Nguyen PM, Gale AJ, Griffin JH. Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C Thromb Haemost. 2009 Jan;101(1):55-61. _x000D_ 6: Regan LM, Lamphear BJ, Huggins CF, Walker FJ, Fay PJ. Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562 J Biol Chem. 1994 Apr 1;269(13):9445-52._x000D_ 7: Bajaj SP, Schmidt AE, Mathur A, Padmanabhan K, Zhong D, Mastri M, Fay PJ. Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa J Biol Chem. 2001 May 11;276(19):16302-9. _x000D_ 8: Uchiba M, Okajima K, Murakami K, Johno M, Okabe H, Takatsuki K. Effect of human urinary thrombomodulin on endotoxin-induced intravascular coagulation and pulmonary vascular injury in rats Am J Hematol. 1997 Feb;54(2):118-23. _x000D_ 9: Takeyama M, Wakabayashi H, Fay PJ. Factor VIII light chain contains a binding site for factor X that contributes to the catalytic efficiency of factor Xase Biochemistry. 2012 Jan 24;51(3):820-8. _x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/22224589">10: Takeyama M, Wakabayashi H, Fay PJ. Factor VIII light chain contains a binding site for factor X that contributes to the catalytic efficiency of factor Xase Biochemistry. 2012 Jan 24;51(3):820-8. </a>_x000D_ <br><strong>Products Related to Human Activated Protein C DEGR (active site blocked) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>