DTS-201 (sodium)
DTS-201 sodium (CPI-0004Na) is a peptidic prodrug of Doxorubicin (HY-15142A) . DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer[1].
Product Specifications
CAS Number
[372491-73-1]
UNSPSC
12352209
Target
Aminopeptidase; Peptide-Drug Conjugates (PDCs)
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dts-201-sodium.html
Smiles
Molecular Formula
C49H64N5NaO18
Molecular Weight
1034.04
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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