Prochlorperazine (dimaleate)

Prochlorperazine dimaleate is a first-generation antipsychotic. Prochlorperazine dimaleate can be used in the research of chemotherapy-induced nausea and vomiting (CINV) . Prochlorperazine dimaleate also possesses anticancer activity. Prochlorperazine dimaleate exhibits IC50 values of 6.4 μM, 4.5 μM and 2.3 μM for NOX1, NOX2 and NOX5, respectively[1][2].

Product Specifications

CAS Number

[84-02-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NADPH Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/prochlorperazine-dimaleate.html

Purity

98.0

Solubility

DMSO : 35.71 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)/C=C\C(O)=O.CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(Cl)C=C24)CC1.O=C(O)/C=C\C(O)=O

Molecular Formula

C28H32ClN3O8S

Molecular Weight

606.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Melissa Lau Moon Lin, et al. The Safety of Prochlorperazine in Children: A Systematic Review and Meta-Analysis. Drug Saf. 2016 Jun;39 (6) :509-16.|[2]Michał Otręba, et al. In vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review. J Appl Toxicol. 2021 Jan;41 (1) :82-94.