(R) -3,4-DCPG
(R) -3,4-DCPG is an AMPA and NMDA antagonist with a Kd of 77 μM for AMPA. (R) -3,4-DCPG complete antagonizes the NMDA-induced depolarization at a concentration of 500 μM. (R) -3,4-DCPG exhibits a weak antagonistic effect on kainate-induced depolarizations[1].
Product Specifications
CAS Number
201730-10-1
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-3-4-dcpg.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C([C@@H](N)C(O)=O)C=C1C(O)=O)O
Molecular Formula
C10H9NO6
Molecular Weight
239.18
References & Citations
[1]N K Thomas, et al. Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur J Pharmacol. 1997 Nov 5;338 (2) :111-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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