Mutant IDH1/NAMPT-IN-1
Mutant IDH1/NAMPT-IN-1 (Compound 23h) is a dual inhibitor of mutant isocitrate dehydrogenase 1 (mutant IDH1) (IC50=14.93 nM) and nicotinamide phosphoribosyltransferase (NAMPT) (IC50=12.56 nM) . Mutant IDH1/NAMPT-IN-1 can induce apoptosis. Mutant IDH1/NAMPT-IN-1 crosses the blood-brain barrier effectively[1].
Product Specifications
CAS Number
3040122-14-0
UNSPSC
12352005
Target
Apoptosis; Isocitrate Dehydrogenase (IDH) ; NAMPT
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mutant-idh1-nampt-in-1.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)NC(COC3=CC=CN=C3)=O)NC4=NC(N5[C@H](COC5=O)[C@H](C)F)=CC=N4
Molecular Formula
C30H29FN6O4
Molecular Weight
556.59
References & Citations
[1]Wen F, et al. Discovery of Novel Dual Inhibitors Targeting Mutant IDH1 and NAMPT for the Treatment of Glioma with IDH1Mutation. J Med Chem. 2024 Apr 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH1
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