VUF14862
VUF14862 is a stable and fatigue-resistant photoswitchable GPCR antagonist targeting the histamine H3 receptor (H3R) pathway. VUF14862 binds to H3R with >10-fold increased affinity upon 360 nm irradiation. VUF14862 can be used for spatiotemporal studies of H3R signaling[1].
Product Specifications
CAS Number
2223023-78-5
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vuf14862.html
Smiles
O=C(C1=CC=CC(/N=N/C2=CC=C(O[C@H]3C[C@H](N4CCCCC4)C3)C=C2)=C1)N5CCCC5
Molecular Formula
C26H32N4O2
Molecular Weight
432.56
References & Citations
[1]Hauwert NJ, et al. Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology. J Am Chem Soc. 2018 Mar 28;140 (12) :4232-4243.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC941930-100 1x 100 µL
PAX5 / BSAP (Early B-Cell Marker) (PCRP-PAX5-1B1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNUB2149-500 1x 500 µL
Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker) (rKRT16/1714), 0.2mg/mL
Sign In for Pricing
View Details 
E1201-E 1 Each
MyGel InstaView™ Complete Electrophoresis System with Blue LED Illuminator, 230V input
Sign In for Pricing
View Details 
AP08472PU-N 50 µg
Porimin (TMEM123) (173-188) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details 