BMS-605541

BMS-605541 is a selective and orally active inhibitor of VEGFR-2 kinase with an IC50 value of 23 nM and Ki value of 49 nM. BMS-605541 inhibits the activity of Flk-1, VEGFR-1 and PDGFR-β with IC50 values of 40 nM, 400 nM and 200 nM, respectively. BMS-605541 can be used for cancer research[1].

Product Specifications

CAS Number

[639858-32-5]

UNSPSC

12352005

Target

PDGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bms-605541.html

Purity

99.57

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=C(C=C(C(F)=C1)C(NC2CC2)=O)NCC3=CN=C(S3)NC4=NC=CC=C4

Molecular Formula

C19H17F2N5OS

Molecular Weight

401.43

References & Citations

[1]Borzilleri RM, et al. Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5- ((2- (pyridin-2-ylamino) thiazol-5- ylmethyl) amino) benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49 (13) :3766-9.