COH-SR4
Product Specifications
UNSPSC Description
COH-SR4 is an AMPK activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders[1].
Target Antigen
AMPK
Type
Reference compound
Related Pathways
Epigenetics;PI3K/Akt/mTOR
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/coh-sr4.html
Purity
99.45
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(Cl)=CC(Cl)=C1)NC2=CC(Cl)=CC(Cl)=C2
Molecular Weight
350.03
References & Citations
[1]James L Figarola, et al. Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation. Int J Mol Med. 2013 May;31(5):1166-76.|[2]James Lester Figarola, et al. COH-SR4 Reduces Body Weight, Improves Glycemic Control and Prevents Hepatic Steatosis in High Fat Diet-Induced Obese Mice. PLoS One. 2013; 8(12): e83801.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124822/COH-SR4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124822/COH-SR4-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
73439-19-7
Available Sizes
Curated Selection
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