Human CNR1 Protein, Flag, His Tag (Detergent)

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.

Product Specifications

Background

Specifications

This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.6 kDa. The protein migrates as 43-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) .

Accession Number

P21554-1

Expression Region

Gly 99 - Val 306 & Pro 332 - Ser 414

Host

Insect Cells

Target

CNR1

Conjugation

Unconjugated

Tag

N-Flag & C-10xHis

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Human CNR1 Protein, Flag,His Tag (Cat. No. CN1-H55D3) at 5 μg/mL (100 μL/well) on Nickel Coated plates (Cat. No. SP-19) can bind Anti-CNR1 Antibody, Human IgG4 with a linear range of 0.6-10 ng/mL (QC tested).