Recoflavone

Recoflavone (DA-6034 (free acid) ), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca (2+) ]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury[1][2][3][4].

Product Specifications

CAS Number

[203191-10-0]

Product Name Alternative

DA-6034 (free acid)

UNSPSC

12352005

Target

Apoptosis; Calcium Channel; COX; ERK; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/recoflavone.html

Purity

98.0

Solubility

DMSO : 40 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C2C(OC(C3=CC(OC)=C(OC)C=C3)=CC2=O)=CC(OCC(O)=O)=C1

Molecular Formula

C20H18O8

Molecular Weight

386.35

References & Citations

[1]Choi SM, et al. Effects of DA-6034, a flavonoid derivative, on mucin-like glycoprotein and ocular surface integrity in a rabbit model. Arzneimittelforschung. 2009;59 (10) :498-503. ; Kwak DS, Lee OY, Lee KN, et al. The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model. Gut Liver. 2016;10 (3) :406-411. |[2]Kwak DS, Lee OY, Lee KN, et al. The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model. Gut Liver. 2016;10 (3) :406-411. ; Kim YW, Lee WH, Choi SM, et al. DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. J Gastroenterol Hepatol. 2012;27 (2) :397-405. |[3]Nam SY, et al. DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis. Exp Biol Med (Maywood) . 2008;233 (2) :180-191.|[4]Yang YM, et al. DA-6034 Induces [Ca (2+) ]i Increase in Epithelial Cells. Korean J Physiol Pharmacol. 2014 Apr;18 (2) :89-94.