Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-FLIPγ/δ (CT) Antibody

Rabbit Polyclonal Antibody specific to FLIP (CT)

Product Specifications

Product Name Alternative

Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]

Gene Name

CFLAR

Gene ID

8837

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=CFLAR">CFLAR</a>

UniProt

O15519

Accession Number

NP_001120655.1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Peptide corresponding to aa 191-209 at the C-terminus of human FLIPdelta/FLIPS form (accession no. AAC51623).

Target Antigen

CASP8 and FADD-like apoptosis regulator

Target

FLIPγ/δ (CT)

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, ICC, IF

Field of Research

Apoptosis

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {PubMed:9880531}.

Additionnal Information

Immunoblotting : use at 1ug/mL. <br><br>Immunocytochemistry: use at 2ug/mL. <br><br>Positive control: Whole cell lysate from HeLa, Jurkat,THP-1, A431, K562, or NIH3T3 cells. <br><br>These are recommended concentrations. <br><br>Enduser should determine optimal concentrations for their applications.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/2407.pdf

Specificity

This antibody recognizes human FLIP&gamma; (35kDa) and FLIP&delta;(25kDa) but not FLIP&alpha; or FLIP&beta;.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Caspase-8 (FLICE) and -10 (FLICE2) are two pivotal members of the ICE/CED-3 protease family. FLICE-inhibitory proteins have been identified in viruses and human cells and are designated v-FLIPs and FLIP, respectively. Human FLIP was cloned by several independent laboratories and designated Casper, I-FLICE, FLAME-1, CASH, and CLARP. FLIP contains two death effector domains and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and -10 and potently inhibits apoptosis induced by death receptors CD95, DR3, TRAIL-R, and TNFR1. Four splice variants of FLIP have been identified and designated FLIP alpha, beta, g, and delta.

CAS Number

9007-83-4

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Mouse Granzyme B Matched Antibody Pair Set [ABP-S-02910]
ABP-S-02910 5 Plates

Mouse Granzyme B Matched Antibody Pair Set [ABP-S-02910]

Ask
View Details
hsa-miR-451b miRNA Inhibitor
MBS8294373-01 10 nmol

hsa-miR-451b miRNA Inhibitor

Ask
View Details
hsa-miR-451b miRNA Inhibitor
MBS8294373-02 20 nmol

hsa-miR-451b miRNA Inhibitor

Ask
View Details
hsa-miR-451b miRNA Inhibitor
MBS8294373-03 5x 20 nmol

hsa-miR-451b miRNA Inhibitor

Ask
View Details
Csnk2a1 (Casein Kinase II Subunit alpha, CK II alpha, Csnk2a1) (MaxLight 750)
MBS6455291-01 0.1 mL

Csnk2a1 (Casein Kinase II Subunit alpha, CK II alpha, Csnk2a1) (MaxLight 750)

Ask
View Details
Csnk2a1 (Casein Kinase II Subunit alpha, CK II alpha, Csnk2a1) (MaxLight 750)
MBS6455291-02 5x 0.1 mL

Csnk2a1 (Casein Kinase II Subunit alpha, CK II alpha, Csnk2a1) (MaxLight 750)

Ask
View Details