F0911-7667
F0911-7667 is a SIRT1 activator that induces autophagic cell death in U87MG and T98G cells by activating the AMPK-mTOR-ULK complex. CWR tripeptide was also identified as a SIRT1 activator that reduced p53 acetylation in IMR32 neuroblastoma cells and protected cells from cell death induced by Aβ fragments[1].
Product Specifications
CAS Number
361198-09-6
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/f0911-7667.html
Smiles
O=C1N(C2=NC3=CC=CC=C3S2)N=C(CSC4=CC=C(Cl)C=C4)/C1=C\NCC5=CC=C(OCO6)C6=C5
Molecular Formula
C26H19ClN4O3S2
Molecular Weight
535.04
References & Citations
[1]A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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