HPK1-IN-51
HPK1-IN-51 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs) . HPK1-IN-51 can be used for synthesis PROTAC PD-L1 degrader-2 (HY-162816) [1].
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-51.html
Smiles
CN(C(C(C=CC(C1=CNC2=C1N=C(C=N2)C3=CC=C(C=C3)C4CCN(C)CC4)=C5)=C5C)=O)C
Molecular Formula
C28H31N5O
Molecular Weight
453.58
References & Citations
[1]Wu M, et al. Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy. J Med Chem. 2024 Aug 22;67 (16) :13852-13878.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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