HPK1-IN-51
HPK1-IN-51 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs) . HPK1-IN-51 can be used for synthesis PROTAC PD-L1 degrader-2 (HY-162816) [1].
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-51.html
Smiles
CN(C(C(C=CC(C1=CNC2=C1N=C(C=N2)C3=CC=C(C=C3)C4CCN(C)CC4)=C5)=C5C)=O)C
Molecular Formula
C28H31N5O
Molecular Weight
453.58
References & Citations
[1]Wu M, et al. Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy. J Med Chem. 2024 Aug 22;67 (16) :13852-13878.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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NALP4 (NACHT-, LRR-and PYD-containing Protein 4, NACHT Leucine Rich Repeat and PYD Containing 4, CLR19.5, FLJ32126, Nucleotide Binding Oligomerization Domain Leucine Rich Repeat and Pyrin Domain Containing 4, NLR Family Pyrin Domain Containing 4, NLRP4, PAAD and NACHT Containing Protein 2, PAN2, PYRIN Containing APAF1-like Protein 4, PYPAF4, Ribonuclease Inhibitor 2, RNH2)
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