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HPK1-IN-51

HPK1-IN-51 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs) . HPK1-IN-51 can be used for synthesis PROTAC PD-L1 degrader-2 (HY-162816) [1].

Product Specifications

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hpk1-in-51.html

Smiles

CN(C(C(C=CC(C1=CNC2=C1N=C(C=N2)C3=CC=C(C=C3)C4CCN(C)CC4)=C5)=C5C)=O)C

Molecular Formula

C28H31N5O

Molecular Weight

453.58

References & Citations

[1]Wu M, et al. Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy. J Med Chem. 2024 Aug 22;67 (16) :13852-13878.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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