Stachybotramide
Stachybotramide is a natural fungal metabolite with the property of modulating the activity of cholesteryl ester transfer protein (CETP) . Stachybotramide stimulates the transfer of cholesteryl esters (CE) from high-density lipoprotein (HDL) to very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), increasing the transfer efficiency by 1.3- to 1.5-fold. Stachybotramide slightly reduced the transfer of cholesteryl esters from LDL and VLDL to HDL at 0.5 mM. The effect of Stachybotramide on the transfer of triglycerides (TG) from HDL was not significant. By these results, Stachybotramide was shown to preferentially stimulate the CETP-mediated transfer of cholesteryl esters from HDL to VLDL and LDL[1].
Product Specifications
CAS Number
[149598-71-0]
UNSPSC
12352005
Target
Fungal
Type
Natural Products
Related Pathways
Anti-infection
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/stachybotramide.html
Smiles
C[C@@]([C@@](C(C)1C)([H])CC2)(CC[C@H]1O)[C@@]3([C@@H]2C)OC4=C(CN5CCO)C(C5=O)=CC(O)=C4C3
Molecular Formula
C25H35NO5
Molecular Weight
429.55
References & Citations
[1]Modulation of the plasma cholesteryl ester transfer by stachybotramide
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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