(S, R, S) -AHPC-C5-COOH

(S, R, S) -AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1].

Product Specifications

CAS Number

[2267282-19-7]

Product Name Alternative

VH032-C5-COOH

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E3 Ligase Ligand-Linker Conjugates; HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-c5-cooh.html

Purity

98.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NCCCCCCC(O)=O

Molecular Formula

C29H42N4O5S

Molecular Weight

558.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Soares P, et al. Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R) -1- ((S) -2- (1-Cyanocyclopropanecarboxamido) -3,3-dimethylbutanoyl) -4-hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide (VH298) .J Med Chem. 2018 Jan 25;61 (2) :599-618.