Fmoc-NH-PEG5-CH2COOH
Fmoc-NH-PEG5-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fmoc-NH-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
[635287-26-2]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmoc-nh-peg5-ch2cooh.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCC(O)=O
Molecular Formula
C27H35NO9
Molecular Weight
517.57
Precautions
H302, H315, H319, H335
References & Citations
[1]Liuhong CHEN, et al. Multimeric bicyclic peptide ligands. WO2019162682A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Cleavable Linker; PEG Linkers
Available Sizes
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POLS, ID (PAPD7, POLS, TRF4, DNA polymerase sigma, DNA polymerase kappa, LAK-1, PAP-associated domain-containing protein 7, Terminal uridylyltransferase 5, Topoisomerase-related function protein 4-1) (MaxLight 650)
