AEOL-10150 (pentachloride)

AEOL-10150 pentachloride is a metalloporphyrin-catalyzed antioxidant and a superoxide dismutase mimetic. AEOL-10150 pentachloride scavenges ROS and RNS, and modulates the NF-κB signaling pathway. AEOL-10150 pentachloride has potent antioxidant and anti-inflammatory activities. AEOL-10150 pentachloride effectively mitigates tissue damage caused by radiation and chemical agents such as CEES (HY-W199190) . AEOL-10150 pentachloride synergizes with radiotherapy to exert anticancer effects on prostate tumors[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[286475-30-7]

UNSPSC

12352005

Target

NF-κB; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aeol-10150-pentachloride.html

Purity

98.0

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC[N+](C=CN1CC)=C1C2=C(C=CC3=C(C(N4CC)=[N+](C=C4)CC)C5=[N]6C(C=C5)=C7C(N8CC)=[N+](C=C8)CC)[N-]3[Mn+3]96[N]%10=C2C=CC%10=C(C(N%11CC)=[N+](C=C%11)CC)C%12=CC=C7[N-]9%12.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]

Molecular Formula

C48H56Cl5MnN12

Molecular Weight

1033.24

References & Citations

[1]Tewari-Singh N, et al. Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects. Free Radic Biol Med. 2014 Jul;72:285-95.|[2]Zhang XR, et al. Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant. Mil Med Res. 2018;5 (1) :30.|[3]Rabbani ZN, et al. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys. 2007 Feb 1;67 (2) :573-80.|[4]O'Neill HC, et al. Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide. Am J Respir Cell Mol Biol. 2011 Aug;45 (2) :323-31. |[5]O'Neill HC, et al. Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide. Free Radic Biol Med. 2010 May 1;48 (9) :1188-96. |[6]Ganesh D, et al. Impact of Superoxide Dismutase Mimetic AEOL 10150 on the Endothelin System of Fischer 344 Rats. PLoS One. 2016 Mar 18;11 (3) :e0151810.|[7]Makinde A Y, et al. Effect of AEOL 10150 on prostate tumor response to radiation. Cancer Research, 2005, 65 (9_Supplement) : 466-466.