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Meclizine-d8

Meclizine-d8 is a deuterium labeled Meclizine. Meclizine is a histamine H1 receptor antagonist and has the potential to treat nausea and motion sickness. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR[1][2][3].

Product Specifications

CAS Number

1246816-06-7

Product Name Alternative

Meclozine-d8

UNSPSC

12352005

Target

Apoptosis; Histamine Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

ClC(C=C1)=CC=C1C(C2=CC=CC=C2)N3C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C3([2H])[2H])CC4=CC=CC(C)=C4

Molecular Formula

C25H19D8ClN2

Molecular Weight

399.00

References & Citations

[1]Priti N. Patel, et al. Safety and Efficacy in the Treatment and Prevention of Motion Sickness.|[2]Vishal M Gohil, et al. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15;20 (2) :294-300.|[3]Wendong Huang, et al. Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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